Eli Lilly, MacroGenics Announce Licensing and Collaboration Agreement

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Eli Lilly and MacroGenics have entered into an alliance to develop and commercialize teplizumab, a humanized anti-CD3 monoclonal antibody, and other potential next-generation anti-CD3 molecules for the treatment of autoimmune diseases.

Lilly will acquire the exclusive rights to teplizumab, which is being studied in the Phase II/III PROTÉGÉ trial for individuals with recent-onset Type 1 diabetes. MacroGenics will continue to oversee the PROTÉGÉ trial.

If teplizumab is commercialized successfully, MacroGenics may receive up to $250 million in potential sales milestones. MacroGenics also would have the option to co-promote teplizumab for certain indications in the U.S., MacroGenics said.