Quality improvement research that poses minimal risk to human subjects, such as a study in which Michigan hospitals implemented checklists and other measures to reduce the rate of catheter-related infections in intensive care units (ICUs), is likely eligible for both expedited IRB review and a waiver of the informed consent requirement, Kristina Borror, director of the Division of Compliance Oversight at the HHS Office for Human Research Protections (OHRP), says.