FDAnews Drug Daily Bulletin
Pharmaceuticals / Research and Development

Circassia’s Cat-SPIRE Sinks in Phase 3 Trial

June 27, 2016

Circassia Pharmaceuticals’ candidate for patients allergic to cats — synthetic peptide immuno-regulatory epitopes — failed in a Phase 3 study, missing its primary endpoint of superiority to placebo in subjects aged 12 to 65 years.

In a clinical trial evaluating 1,245 subjects, the Cat-SPIRE candidate reduced allergy symptoms in almost 60 percent of patients versus placebo at 58.5 percent.

Moving forward, the company will focus on advancing its NIOX asthma management products.

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