Home » Novartis’ Siponimod Achieves Phase III Endpoint in MS Trial
Novartis’ Siponimod Achieves Phase III Endpoint in MS Trial
Novartis’ siponimod met its primary endpoint in a Phase III trial, reducing the risk of three-month confirmed disability progression in secondary progressive multiple sclerosis.
The EXPAND randomized study — the largest ever for SPMS, enrolling 1,651 patients from 31 countries — compared oral, once-daily siponimod (BAF312) to placebo. Top-line results are planned to be presented as a late-breaking oral abstract at the Congress of the European Committee for Treatment and Research in Multiple Sclerosis on Sept. 17 in London.
Siponimod is a selective modulator of specific types of the sphingosine-1-phosphate receptor.
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