CYTOKINETICS BEGINS TRIAL FOR TREATMENT OF ACUTE HEART FAILURE

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Cytokinetics has initiated a Phase I clinical trial with CK-1827452, a small-molecule activator of cardiac myosin, for the treatment of patients with heart failure. CK-1827452 is the first clinical drug candidate to arise from the company's cardiac myosin activator program.

The clinical trial is a double-blind, randomized, placebo-controlled trial being conducted to investigate the safety, tolerability, pharmacokinetic, and pharmacodynamic profile of CK-1827452 in normal healthy volunteers. This dose-escalation trial is designed to identify the maximally tolerated dose of a six-hour intravenous infusion of CK-1827452. The effect of CK-1827452 on the left ventricular function of these healthy volunteers will be evaluated using serial echocardiograms.