CYTOKINETICS BEGINS TRIAL FOR TREATMENT OF ACUTE HEART FAILURE
Cytokinetics has initiated a Phase I clinical trial with CK-1827452, a small-molecule
activator of cardiac myosin, for the treatment of patients with heart failure.
CK-1827452 is the first clinical drug candidate to arise from the company's
cardiac myosin activator program.
The clinical trial is a double-blind, randomized, placebo-controlled trial being
conducted to investigate the safety, tolerability, pharmacokinetic, and pharmacodynamic
profile of CK-1827452 in normal healthy volunteers. This dose-escalation trial
is designed to identify the maximally tolerated dose of a six-hour intravenous
infusion of CK-1827452. The effect of CK-1827452 on the left ventricular function
of these healthy volunteers will be evaluated using serial echocardiograms.
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