NEWLY PUBLISHED DATA DEMONSTRATES ACTIVITY OF QUADRAMET
Cytogen has announced the publication of data from a study of Quadramet (samarium
Sm-153 lexidronam injection), in combination with gemcitabine (Gemzar, Eli Lilly),
a nucleoside analog that is known to be a radiation sensitizer. The majority
of patients with advanced-stage disease who were treated with the combination
regimen demonstrated an improvement in imaging studies. Results were published
today in the peer-reviewed journal Clinical Cancer Research.
The study was conducted by independent investigators who evaluated the use of
high-dose Quadramet in conjunction with gemcitabine for the treatment of osteosarcoma.
In the study, 14 patients with osteoblastic lesions of relapsed, resistant,
and/or refractory osteosarcoma for which surgical control was not possible received
30 mCi/kg of Quadramet, significantly higher than the standard palliative dose
of 1.0 mCi/kg. Gemcitabine was then administered one day later, followed by
stem cell or bone marrow support two weeks later to correct expected hematopoietic
toxicity.
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