AMGEN ANNOUNCES RESULTS OF ARANESP TRIAL

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Amgen has announced interim results from a multicenter, randomized, double-blind, placebo-controlled, Phase III trial of Aranesp (darbepoetin alfa) administered every three weeks in cancer patients with chemotherapy-induced anemia. The study revealed that Aranesp increased and maintained patient hemoglobin levels to the target level of greater than or equal to 11 grams per deciliter (g/dL) and reduced the need for red blood cell transfusions by almost half compared to placebo.

Eligible patients had been diagnosed with anemia (hemoglobin levels less than 11g/dL) and non-myeloid malignancy with at least 12 weeks of planned chemotherapy. Patients enrolled in the study had mean hemoglobin concentrations at baseline of approximately 10 g/dL in both the Aranesp and placebo groups.