Synthetic Blood International has reported the treatment of the fourth patient in its eight-patient Phase II proof-of-concept Oxycyte study in traumatic brain injury. Cerebral oxygen tension following Oxycyte administration was significantly increased in this patient, consistent with the results in the first three patients.
The Phase II pilot study protocol includes two groups. The first four study patients were stabilized with 50 percent oxygen for four hours before and 12 hours following Oxycyte administration. The remaining four study patients will breathe 100 percent oxygen on the same schedule. Clinical data on brain oxygen and metabolite levels will be compared in patients from both groups.