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GEMIN X REPORTS CANCER TREATMENT STUDY RESULTS
Gemin X Biotechnologies has announced that results from a Phase I clinical trial of GX15-070 in patients with refractory solid tumors and lymphomas showed the compound to be generally well-tolerated at doses resulting in biological activity.
The clinical trial enrolled 18 patients with refractory solid tumors or lymphomas who had failed a median of four prior types of treatment. All patients were treated with GX15-070 at doses ranging from 5 mg/m2 to 20 mg/m2 administered as a three-hour, weekly infusion in four week cycles. Clinical responses achieved to date include six patients with stable disease from 15 to 47 weeks. Biological responses include a mean increase in plasma oligonucleosomal DNA levels of 7-fold over baseline, indicating successful induction of apoptosis. Additionally, Cmax and AUC were dose-proportional. Adverse events were mostly observed during or shortly after infusion and were transient. Side effects commonly associated with cancer treatments including neutropenia, thrombocytopenia or lymphopenia were not observed.
KEYWORDS Drug Pipeline Alert
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