GlaxoSmithKline has received FDA approval for Avandamet (rosiglitazone maleate and metformin HCl) for use as initial treatment of Type 2 diabetes as an adjunct to diet and exercise. Avandamet was previously approved as a second-line therapy -- it was indicated for use in patients who were uncontrolled on metformin monotherapy. Now, with this recent approval, physicians can start their Type 2 diabetes patients on Avandamet.
Avandamet is the only combination of a thiazolidinedione, rosiglitazone maleate (separately marketed as Avandia) and metformin HCl with approved use as initial therapy of Type 2 diabetes. The drug is indicated as an adjunct to diet and exercise to improve glycemic control in patients with Type 2 diabetes mellitus when treatment with dual rosiglitazone and metformin therapy is appropriate.