Too Many Small Studies Among Flaws Seen in U.S. Trials Enterprise

Clinical trial stakeholders must look for opportunities to join forces on larger, more meaningful studies to boost trial efficiency, a Duke University researcher says. A new study shows that of the nearly 100,000 trials registered with ClinicalTrials.gov as of Sept. 27, 2010, 96 percent had an anticipated enrollment of 1,000 or fewer participants and 62 percent had 100 or less. Many of these studies are conducted at a single trial site, according to the analysis led by Robert Califf, Duke Translational Medicine Institute. The study was published in the May 2 Journal of the American Medical Association (JAMA).
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