FDAnews
www.fdanews.com/articles/148904-gilead-8217-s-pah-candidate-scrapped-after-missing-primary-endpoint-in-study

Gilead’s PAH Candidate Scrapped After Missing Primary Endpoint in Study

August 23, 2012
Gilead Sciences’ pulmonary arterial hypertension (PAH) drug cicletanine did not meet its primary endpoint in a Phase II trial, leading Gilead to terminate the study and drop plans to further develop the drug for PAH. Cicletanine, an oral, once-daily drug approved in some EU countries to treat hypertension, was not significantly better than placebo for helping patients with PAH walk farther in a six-minute walking test at 12 weeks.
Drug Industry Daily