www.fdanews.com/articles/178235-novartis-siponimod-achieves-phase-iii-endpoint-in-ms-trial
Novartis’ Siponimod Achieves Phase III Endpoint in MS Trial
September 2, 2016
Novartis’ siponimod met its primary endpoint in a Phase III trial, reducing the risk of three-month confirmed disability progression in secondary progressive multiple sclerosis.
The EXPAND randomized study — the largest ever for SPMS, enrolling 1,651 patients from 31 countries — compared oral, once-daily siponimod (BAF312) to placebo. Top-line results are planned to be presented as a late-breaking oral abstract at the Congress of the European Committee for Treatment and Research in Multiple Sclerosis on Sept. 17 in London.
Siponimod is a selective modulator of specific types of the sphingosine-1-phosphate receptor.