Radioligand Prostate Therapy Shows Promise in Late-Stage Trial

March 24, 2021

Novartis has announced positive results from a phase 3 trial of its radioligand therapy, Lu-PSMA-617, for treatment of progressive prostate-specific membrane antigen (PMSA)-positive metastatic castration-resistant prostate cancer.

Radioligand therapy delivers targeted radiation to tumors in a way that limits damage to the surrounding tissue. A radioligand is made of two parts, a ligand — an ion or molecule — that binds with specific cancer cell molecules and a radioisotope that emits radiation to kill the cells.

Lu-PSMA-617 therapy significantly improved overall survival and radiographic progression-free survival, Novartis said, adding that the positive results will support applications for approval in the U.S. and EU.

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