FDAnews
www.fdanews.com/articles/72691-corgentech-treats-first-patient-in-phase-i-ii-trial-of-eczema-drug-candidate

Corgentech Treats First Patient in Phase I/II Trial of Eczema Drug Candidate

May 25, 2005

Corgentech has begun treating patients in a multicenter Phase I/II clinical trial of its NF-kappaB Decoy (NF-kB Decoy) drug candidate for the treatment of atopic dermatitis, a chronic skin disease also known as eczema that affects about 15 million adults in the U.S.

This is the first of two Phase I/II trials to be initiated. The second trial will be conducted in Australia and Switzerland in approximately 120 patients and is expected to initiate enrollment by mid-2005.

The multicenter, randomized, double-blind, dose-ranging trial will evaluate the safety and feasibility of repeated application of three concentrations of NF-kB Decoy to the skin of adult patients with mild-to-moderate eczema. NF-kB Decoy is a highly selective and potent inhibitor of the transcription factor, NF-kB, which is implicated in inflammatory diseases such as eczema, asthma and inflammatory bowel disease.