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Exelixis and Helsinn Sign Agreement for XL119

June 13, 2005

Exelixis and Helsinn Healthcare S.A. reached an agreement for the development of XL119. Under the terms of the agreement, Helsinn will pay Exelixis an upfront payment of $4 million and additional milestones up to $21 million. In addition, Helsinn will assume the cost of the Phase III program going forward. In return, Exelixis has granted to Helsinn a worldwide, royalty-bearing license to XL119. Exelixis has retained rights to reacquire commercial rights to XL119 for North America, and will receive milestones and royalties on sales in the rest of the world.

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