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Notice Regarding Change of Trade Name

June 13, 2005

Chugai Pharmaceutical announced today that the trade name of Chugai-Aventis S.N.C., one of Chugai's consolidated overseas subsidiaries, will be changed. Reason for the change: As result of the trade name change of the joint venture partner from Aventis-Pharma S.A. to sanofi-aventis, pursuant to the acquisition of Aventis by Sanofi-Synthelabo (which has changed its trade name to sanofi-aventis). New trade name: CHUGAI sanofi-aventis SNC. Date of the change:

June 17, 2005 (scheduled date for the registration of alteration).

PharmaLive (http://www.medadnews.com/News/Index.cfm?articleid=247747)