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PARADIGM AND TAKEDA ENTER INTO ALLIANCE

June 30, 2005

Paradigm Therapeutics and Takeda Pharmaceutical announced that both parties have agreed to enter into a therapeutic area alliance in the field of CNS diseases. Under terms of the initial three year agreement, Paradigm will provide to Takeda exclusive access to proprietary drug targets in defined CNS fields, with selected targets being subject to further validation by Paradigm and subsequent screening and development carried out at Takeda. The deal anticipates the identification of multiple targets through each year of the collaboration. The initial agreement also allows for further extension of the collaboration by mutual agreement.

PharmaLive (http://www.pharmalive.com/News/index.cfm?articleid=252826&categoryid=21)