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REGISTRATION STATEMENT FOR RESALE OF $250 MILLION CONVERTIBLE SENIOR NOTES DECLARED EFFECTIVE BY SEC

August 15, 2005

Protein Design Labs, Inc. (PDL) (Nasdaq: PDLI - News) announced today that the Form S-3 Registration Statement filed in connection with the 2.00% Convertible Senior Notes due 2012 in an aggregate amount of $250.0 million has been declared effective by the U.S. Securities and Exchange Commission. The offering was completed in February 2005 pursuant to Rule 144A under the Securities Act of 1933, as amended.

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