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ENTREMED AND THE NATIONAL CANCER INSTITUTE COMMENCE RESEARCH COLLABORATION

September 15, 2005

EntreMed, Inc. (Nasdaq: ENMD - News), a clinical-stage pharmaceutical company developing therapeutics primarily for the treatment of cancer and inflammatory diseases, today announced that it has entered into a Cooperative Research and Development Agreement (CRADA) with the National Cancer Institute to evaluate the role of HIF-1alpha inhibition in the treatment of cancer.

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