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ONCOLYTICS BIOTECH INC. ANNOUNCES ISSUANCE OF THIRD CANADIAN PATENT

October 20, 2005

Oncolytics Biotech Inc. (TSX: ONC, NASDAQ: ONCY) ("Oncolytics") has been granted Canadian Patent 2,283,280 entitled "Reovirus for the treatment of neoplasia." The claims describe the use of a reovirus for the manufacture of a medicament to treat Ras-mediated neoplasia as well as methods of treating various cancers by the administration of the reovirus.

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