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DISCOVERY PARTNERS INTERNATIONAL ANNOUNCES DRUG DISCOVERY COLLABORATION WITH MITSUBISHI PHARMA

October 27, 2005

Discovery Partners International, Inc. (Nasdaq: DPII) announced today that they have entered into a new drug discovery collaboration with Mitsubishi Pharma Corporation

(Mitsubishi) to discover lead compounds for a therapeutic target selected by Mitsubishi. DPI will make use of its comprehensive drug-like compound collection and leverage its expertise in assay development, high-throughput screening, and computational chemistry. Financial terms of the collaboration and the therapeutic focus of the collaboration were not disclosed.

PR Newswire (http://www.prnewswire.com/cgi-bin/stories.pl?ACCT=104&STORY=/www/story/10-26-2005/0004195385&EDATE=)