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ISIS PHARMACEUTICALS REPORTS FINANCIAL RESULTS AND HIGHLIGHTS FOR THE THIRD QUARTER 2005

November 9, 2005

Isis Pharmaceuticals, Inc. (Nasdaq: ISIS) today announced its financial results for the third quarter of 2005. The Company's proforma loss from operations decreased significantly to $12.5 million and $41.8 million for the three and nine months ended September 30, 2005, respectively, compared to a proforma loss from operations of $22.8 million and $66.7 million for the same periods in 2004.

PR Newswire (http://www.prnewswire.com/cgi-bin/stories.pl?ACCT=104&STORY=/www/story/11-08-2005/0004210599&EDATE=)