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BIOCRYST ANNOUNCES $30.0 MILLION COMMON STOCK OFFERING TO INSTITUTIONAL INVESTORS

December 15, 2005

BioCryst Pharmaceuticals, Inc. today announced that it has signed a definitive agreement for a $30.0 million registered direct offering of 2,228,829 shares of its common stock to a group of institutional investors including Kleiner Perkins Caufield & Byers and Texas Pacific Group Ventures. The shares of common stock, priced at $13.46 per share, were registered pursuant to BioCryst's shelf registration statements that were declared effective by the Securities and Exchange Commission on January 5, 2004 and September 20, 2005.

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