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BIOPURE ANNOUNCES PRICING OF EQUITY OFFERING

December 21, 2005

Biopure Corporation today announced the pricing of an underwritten public offering of common stock and warrants. Subject to closing conditions, the underwriters have agreed to purchase 8,800,000 new shares of Biopure common stock and warrants to acquire an additional 8,800,000 new shares. The price for one share and one warrant is $0.68, and the exercise price of each warrant is $0.85.

PR Newswire (http://www.prnewswire.com/cgi-bin/stories.pl?ACCT=104&STORY=/www/story/12-21-2005/0004237721&EDATE=)