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www.fdanews.com/articles/84460-genzyme-launches-key-test-to-monitor-gleevec-resistance

GENZYME LAUNCHES KEY TEST TO MONITOR GLEEVEC RESISTANCE

February 9, 2006

Genzyme Corporation announced today the availability of an important new test to monitor drug resistance in chronic myeloid leukemia (CML) patients who are treated with Gleevec (imatinib mesylate). Despite high response rates to Gleevec, approximately four to five percent of patients who were initially treated successfully will develop resistance during therapy. Genzyme's new BCR-ABL Mutation Analysis test will assist physicians in evaluating resistance to therapy and facilitate appropriate adjustments to treatment.
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