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PRECLINICAL DATA FOR TRANSITION'S AZD-103 PRESENTED AT CONFERENCE

February 24, 2006

Transition Therapeutics has presented positive preclinical data with its Alzheimer's disease lead product AZD-103 at the Keystone Symposia on Alzheimer's Disease, held in Breckenridge, Colo.

A series of preclinical studies in a widely accepted animal model of Alzheimer's disease showed that AZD-103 can prevent and reduce disease effects including the formation of amyloid beta fibrils, impaired cognitive function and accelerated mortality. These outcomes occurred regardless of whether AZD-103 was administered before the onset of disease or during the symptomatic phase of disease indicating AZD-103's potential as a preventative and therapeutic agent for Alzheimer's disease.