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ZONAGEN REPORTS FOURTH QUARTER AND YEAR END 2005 FINANCIAL RESULTS

March 13, 2006

Zonagen, Inc. today announced financial results for the year and fourth quarter ended December 31, 2005 and provided an update on the Proellex clinical program.
Total revenues for 2005 were $634,000 as compared to $257,000 for 2004. Research and development grants for 2005 were $4,000 as compared to $118,000 for 2004 relating to the Company's Small Business Innovative Research ("SBIR") grants.
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