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www.fdanews.com/articles/85888-vertex-announces-initiation-of-development-program-for-aurora-kinase-inhibitor

VERTEX ANNOUNCES INITIATION OF DEVELOPMENT PROGRAM FOR AURORA KINASE INHIBITOR

April 7, 2006

Vertex Pharmaceuticals has begun a Phase II clinical development program for VX-680, an investigational drug candidate targeting Aurora kinase.

The initiation of Phase II development for VX-680 is based on the enrollment of patients with advanced colorectal cancer who may have received up to three prior cancer treatments. The open-label, non-randomized study will enroll approximately 20 patients and is being conducted at major cancer treatment centers in the U.S.