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www.fdanews.com/articles/85927-medimmune-s-abegrin-helpful-in-treating-solid-tumors

MEDIMMUNE'S ABEGRIN HELPFUL IN TREATING SOLID TUMORS

April 10, 2006

MedImmune has reported that preclinical and clinical data showed that Abegrin may provide a three-pronged approach to treat solid tumors. Abegrin is a monoclonal antibody that targets the alpha-v beta-3 integrin, which is a protein expressed on the surface of newly forming blood vessels, certain tumor types.

According to the company, results from the preclinical studies indicated that its mechanism of anti-tumor action may involve both direct and indirect effects on a tumor's ability to grow or spread. Majority of Abegrin's antitumor activity is likely mediated through antibody-dependent cellular cytotoxicity, the company stated.