AXONYX ANNOUNCES COMPLETION POSIPHEN STUDY

Axonyx has announced the completion of its second Phase I study with Posiphen in clinical development for the treatment of Alzheimer's disease progression.

This double-blind, placebo-controlled multiple ascending-dose safety and pharmacokinetic study of Posiphen in healthy volunteers sought to establish well tolerated doses. The initial review of the clinical adverse event data appears to be generally consistent with the results of the earlier single-ascending-dose Phase I study that suggested that the mean Posiphen blood levels associated with well tolerated doses in humans are higher than those associated with potentially beneficial effects on beta-amyloid metabolism in animal models.