ISIS REPORTS POSITIVE DATA FOR ISIS 113715

Isis Pharmaceuticals has announced positive Phase II results in patients with Type 2 diabetes treated with ISIS 113715 as a single-agent.

An intent-to-treat analysis of all patients enrolled in the trial treated with 200 mg/wk for three months showed statistically significant improvement in multiple measures of glucose control. ISIS 113715 did not cause hypoglycemia (low blood sugar), did not cause weight gain and was well tolerated. ISIS 113715, a second-generation antisense drug, is a novel insulin sensitizer that reduces the expression of protein tyrosine phosphatase-1B (PTP-1B). PTP-1B is a mediator of insulin resistance, one of two main defects in patients with Type 2 diabetes.